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Say NO to Hyaluronic Acid!

One of our deepest dives yet. This took nearly 2 months to research and put together. But it’s important to get to the truth. We tried to squeeze everything in and yet keep it accessible.

What did we miss?

Who is the YouTube famous dermatologist who doesn’t understand that all HA penetrates into the dermis?

0:00 Intro and welcome to Paige Elkington, model, actress, comedian, and skincare deep diver.

0:52 Why hyaluronic acid is the worst possible choice as a moisturizer.

1:28 How hyaluronic acid pokes holes in your skin.

2:49 The holes made by hyaluronic acid expand with use.

3:43 Does the apply-to-wet skin hack work?

4:34 How hyaluronic acid got its cult status.

5:16 Does hyaluronic acid hold 1000x its weight in water?

6:27 Why is hyaluronic acid in everything?

6:49 Companies use hyaluronic acid as a penetrant?

7:54 Hyaluronic acid makes the skin sensitive.

8:50 Hyaluronic acid makes already sensitive skin worse.

9:54 There is one reason for using hyaluronic acid.

10:50 All forms of hyaluronic acid penetrate the skin.

12:04 Dermatologists are not stupid, they just don’t have the time.

12:57 Conclusion

13:23 Two important final points: hyaluronic acid doesn’t decline with age and it’s arranged in a highly complex way in the skin.

Citations:

How HA distorts the lipid mortar structure of the stratum corneum.

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S. Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules. Mol Pharm. 2015 May 4;12(5):1391-401. doi: 10.1021/mp500676e. Epub 2015 Apr 22. PMID: 25871518.

https://pubmed.ncbi.nlm.nih.gov/25871…

How HA aggravates skin sensitization:

Esser PR, Wölfle U, Dürr C, von Loewenich FD, Schempp CM, Freudenberg MA, Jakob T, Martin SF. Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation. PLoS One. 2012;7(7):e41340. doi: 10.1371/journal.pone.0041340. Epub 2012 Jul 25. PMID: 22848468; PMCID: PMC3405137.

https://pubmed.ncbi.nlm.nih.gov/22848…

All molecular weights of HA penetrate the skin.

https://juniperpublishers.com/jojdc/p…

How the amount of HA in the skin does not change with age.

https://pubmed.ncbi.nlm.nih.gov/8120424/

How HA behaves differently in the context of a wound than in the context of intact skin.

https://pubmed.ncbi.nlm.nih.gov/24058…

How large molecular weight HA can deliver huge molecules like human growth hormone through the skin

https://pubmed.ncbi.nlm.nih.gov/22632…

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