In this article:
- The Root Cause for Saggy, Menopause Skin: Bloated Fat Cells
- What’s the link between bloated fat cells and sagging?
- Fat Cell Size Increases During the Menopause Transition
- Adipeau Has a New Approach to Saggy Menopause Skin
- Adipeau Works Better with Other Holistic Modalities
- How It Works
- Conclusion
Saggy, menopause skin can be frustrating, but understanding the root cause—bloated fat cells—may help you fix it. In this article, we’ll explore the science behind saggy menopause skin, why fat cells bloat during menopause, and how Adipeau’s approach aims to restore firmness.
The Root Cause for Saggy, Menopause Skin: Bloated Fat Cells
To solve it, you have to address the root cause:
Bloated fat cells.
What’s the link between bloated fat cells and sagging?
Shiseido assessed visible sagging of the lower face (a), skin elasticity (b and c) and fat tissue size (d). 2010 PMID: 20637003.
Source: 2010 PMID: 20637003
Results: Fat size explains almost all of the
elasticity loss with age.
The results showed that the correlation between fat size (-0.30) and elasticity was almost the same as the correlation between age (-0.33) and elasticity.
Results: Fat size explains sagging better than skin elasticity!
Compared to dermal elasticity measurements (Ua/Uf), fat size (e.g., thickness of the s.c. layer) has a higher absolute correlation (0.442 v. .358) and a much lower P-value (.0001 vs .002).
How do bloated fat cells cause saggy skin?
In these mechanistic studies, Shiseido compared small, healthy fat cells (“Day 8 adipocytes”) to bloated, inflammatory fat cells (“Day 21 adipocytes”).
Source: 2011. PMID: 21697886
1. Bloated Fat Cells Kill Fibroblasts.
Day 21 adipocytes cause a highly significant reduction in the number of fibroblasts (e.g., cell abundance) of greater than 30%.
2. Bloated Fat Cells Suppress Collagen and Elastin Production
Day 21 adipocytes cause highly significant reductions in collagen (~70 percent) and elastin (~60 percent).
3. Bloated Fat Cells Fuel Collagen Degradation
Day 21 adipocytes increase the levels of MMP13, an enzyme that degrades collagen, by more than 300 percent.
Fat Cell Size Increases During the Menopause Transition
While it is well known that the body composition changes during menopause, this small clinical study was the first to take biopsies to document that fat cell volume increases considerably during menopause.
Source: 2019 PMID: 30843880
Cells Bloat as Fat Mass Grows Faster Than Body Weight
The change in fat cell size reflects the fact that normalized body weight increase by about 4% during the menopause transition, while normalized fat mass increases more than 3x higher, by 12%.
Bloated Fat Cells Suppress New Fat Cell Recruitment (e.g., Adipogenesis)
It is known in the field of obesity, that hypertrophic or bloated fat cells will suppress new fat cell formation. In this study, body mass index (c) and fat cell size (d) were negatively correlated with adipogenesis of new cell formation.
Source: 2009 PMID: 19351711
Fat Cell Numbers Fall During Menopause Transition
In the Greendale et al menopause body composition study also showed that fat cell numbers decline druing the menopause transition. The decline was not statistically significant because the study was quite small.
The Menopause Vicious Cycle
The evidence suggests that menopause sets off a vicious cycle, where bloated fat cells cause a reduction in new fat cell formation, which causes mature fat cells to get even bigger, which further reduces new fat cell formation.
Adipeau Has a New Approach to Saggy Menopause Skin
In 2020, we published a new paradigm for thinking about fat cell health in the context of aesthetics. This peer-reviewed paper discusses the importance of small, anti-inflammatory fat cells for healthy, voluminous skin.
Source: 2020 PMID 32914326
We reverse the vicious cycle by decreasing fat cell size and increasing new fat cell formation.
Our innovative approach of reducing fat cell size and stimulating adipogenesis has been awarded a broad patent by the USPTO. You can read the patent application on google or download the granted patent from the USPTO website.
The Karolinska Institute has validated our formulas.
Our active ingredients can double the number of cells while maintaining or decreasing cell size.
The Real Proof Is in the Selfies
The best evidence of efficacy comes from real people. These Adipeau users sent us their photographs to document their changes. What’s most notable is the reduction in weakness in the lower face, and the restoration of a triangular appearance of the face. See more results here.
Adipeau Works Better with Other Holistic Modalities
You can get better results by taking care of your body. Exercise increases blood flow and reduces fat cell size. Protein rich diet stimulates adipogenesis, as does an anti-inflammatory diet. Preventing the accumulation of lymph fluid also helps reduce cell size. Stress dramatically reduces adipogenesis.
How It Works
Two active ingredients: Poly-methoxy-flavonoids (PMFs) from Kaempferia Parviflora Extract and long chain fatty acids (LCFAs) from safflower seed oil
The face cream balances PMFs and LCFAs.
The body gel has a higher concentration of PMFs and almost no LCFAs.
Conclusion
Menopause triggers hormonal shifts that can lead to bloated, inflammatory fat cells, ultimately causing saggy skin. By focusing on reducing fat cell size and encouraging healthy new fat cell formation, Adipeau offers a targeted approach to breaking this vicious cycle. Combine Adipeau’s formulas with holistic lifestyle choices—like exercise, a protein-rich diet, and stress management—to maximize results and restore a firmer, more youthful appearance.
