Have you wondered about cellulite?
There are three questions that have long puzzled me.
1) Why do women get cellulite and men don’t?
2) Why do even skinny women have cellulite?
3) Why does cellulite manifest predominantly in the thighs and buttocks?
Then I saw an instagram post from Body Studio LLC with a picture of what looked very much like cellulite on the chin of a patient who had lipoplasty.
And the key word “fibrosis.”
This word was the missing piece that helped put the other pieces into place.
We introduce for the first time a fat cell size-centric view of cellulite.
Fat cell size explains all of the hallmarks of cellulite better than any other single factor.
Of course, other factors play a role — such as genetics, overall body health, etc.
But fat cell size seems to the proximate factor that drives cellulite.
Here are the peer-reviewed sources for all of those who love to look at the underlying findings.
The excellent histology paper that documents what’s really going on in cellulite tissue.
https://www.ncbi.nlm.nih.gov/pmc/arti…
Paper can be downloaded for free.
The source of the cartoon showing large fat cells generating inflammatory markers:
Obesity and inflammatory skin diseases, Trends in Immunotherapy (2017) Volume 1 Issue 2,
Satoshi Nakamizo, Tetsuya Honda, Kenji Kabashima.
The paper providing clinical evidence that a 10% increase in fat cell size leads to 100% or more increases in inflammatory markers.
https://pubmed.ncbi.nlm.nih.gov/25148…
Paper can be downloaded for free.
The paper that explains how large fat cells secrete factors that downregulate elastin and collagen, and upregulate collagen degrading enzymes.
https://pubmed.ncbi.nlm.nih.gov/21697…
Paper can be downloaded for free.
The post from body studio LLC that triggered the “Aha.”
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The paper that documents the clinical data for how deoxycholic acid causes fat cell lysis, inflammation and fibrotic septa.
https://pubmed.ncbi.nlm.nih.gov/37073…
Paper can be downloaded for free.
The data on fat cell size in women vs men and in buttocks and thighs vs arms and chest were obtained from ChatGPT.
Search prompts used were “What is the diameter of dermal adipocytes in women compared to the diameter of dermal adipocytes in men?” And “What is the diameter of dermal adipocytes in the buttocks and thighs compared to the diameter of dermal adipocytes in the arms and chest?”
